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EECP Research

Below are some of the myriad clinical research studies being performed world-wide featuring EECP. For a comprehensive compilation of research, please visit Vasomedical, Inc., owner of the registered trademark EECP:

  • EECP is a Regenerative Disease, Frontiers in Bioscience, Jan. 1, 2010
  • Enhanced External Counterpulsation Attenuates Atherosclerosis Progression Through Modulation of Proinflammatory Signal Pathway, Arterioscler Thromb Vasc Biol 2010;30;773-780; originally published online Feb 11, 2010 John C.K. Hui and Zhensheng Zheng Zhimin Du, Yugang Dong, Yafei Jin, Wen He, Kuijian Wang, William E. Lawson,Yan Zhang, Xiaohong He, Donghong Liu, Guifu Wu, Xiaolin Chen, Hong Ma
  • Journal of Geriatric Cardiology, June 2010; Acute hemodynamic effects of enhanced external counterpulsation; Bhavananda T. Reddy, Andrew D. Michaels Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah, United States.
  • India Heart Journal, 2010 Enhanced External Counterpulsation (EECP) Therapy: Current Evidence For Clinical Practice And Who Will Benefit?
    G. N. Prasad, S. Ramasamy, Joy M.Thomas, Pradeep G. Nayar, Madhu N. Sankar, N. Sivakadaksham, K. M. Cherian, Dr. K.M.Cherian’s Frontier Lifeline Hospital, Chennai, Tamil Nadu Siva’s Cardiac Care Clinic.
  • Impact of Enhanced External Counterpulsation on Canadian Cardiovascular Society Angina Class in Patients with Chronic Stable Angina: A Meta-analysis; Sachin A. Shah, Pharm.D., Robert J. Shapiro, Pharm.D., Rina Mehta, Pharm.D., and Jeffrey A. Snyder, Pharm.D.
  • Enhanced External Counterpulsation-A Review; LA Sayami, M Ullah, MT Rahman, Z Rahman, D Roy, AAS Majumder; Department of Cardiology, NICVD, Dhaka, Bangladesh.(Cardiovasc. j. 2010; 2(2) : 236-244)
  • Spine, 2010 Jul 1;35(15):1415-22.Enhanced external counterpulsation and traction therapy ameliorates rotational vertebral artery flow insufficiency resulting from cervical spondylosis.Xin W, Fangjian G, Hua W, Jiangtao X, Shouyi W, Yingchun Z, Xiong L.Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, People's Republic of China.
  • Enhanced External Counter Pulsation (EECP) for Refractory Angina Pectoris (RAP); Results from a first case series Waqas Ahmed, Naveed Akhter, Ayesha Masood Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan; 2010
  • Circulation published online Oct 4, 2010; Khuddus, Darren T. Beck and Darren P. Casey, Randy W. Braith, C. Richard Conti, Wilmer W. Nichols, Calvin Y. Choi, Matheen A. Sham-Controlled Study Flow-Mediated Dilation in Patients With Chronic Angina. A RandomizedEnhanced External Counterpulsation Improves Peripheral Artery
  • Heart 2010 96: 202-207 originally published online November 5, 2009 Steffen Gloekler, Pascal Meier, Stefano F de Marchi, et al.Coronary collateral growth by external counterpulsation: a randomised controlled trial; http://heart.bmj.com/content/96/3/202.full.html
  • Journal of  Geriatric Cardiology, June 2010; Role of external counterpulsation in the treatment of ischemic stroke Jing-Hao Han, Wai-Hong Leung, Ka-Sing Wong Departments of Medicine & Therapeutics; The Chinese University of Hong Kong, Shatin, Hong Kong SAR
  • Journal of Geriatric Cardiology, June 2010; EECP in the treatment of endothelial dysfunction: preventing progression of cardiovascular disease; John CK Hui, William E Lawson, Gregory W Barsness
  • Journal of Geriatric Cardiology, June 2010; The four stages of development: a historical prospective of external counterpulsation; John CK Hui, Zhen-Sheng Zheng
  • Cerebrovascular Disease, Oct. 2010; Does External Counterpulsation Augment Mean Cerebral Blood Flow in the Healthy Brain? Effects of External Counterpulsation on Middle Cerebral Artery Flow Velocity and Cerebrovascular Regulatory Response in Healthy Subjects; G.J. Jungehuelsing a T.G. Liman a P. Brunecker a A. Ebel a M. Endres a I. Buschmann b N. Pagonas b E.E. Buschmann b, c on behalf of the Arteriogenesis Network and of the Center for Stroke Research Berlin a Center for Stroke Research Berlin, Department of Neurology, and Arteriogenesis Research, Department of Cardiology and Center for Cardiovascular Research, Charité University Medicine Berlin, and c Department of Cardiology, Helios Klinikum Berlin Buch, Berlin, Germany
  • International Journal of Cardiology, 2010; Effect of enhanced external counterpulsation on circulating CD34+ progenitor cell subsets; T.J. Kiernan 1, B.A. Boilson 1, L. Tesmer, A. Harbuzariu, R.D. Simari, G.W. Barsness
  • ARYA Atherosclerosis Journal, 2009; Effect of Enhanced External Counter Pulsation on Plasma Level of Nitric Oxide and Vascular Endothelial Growth Factor. Masoud Pourmoghadas(1), Hajar Nourmohamamadi(2), Faezeh Tabesh(2), Shaghayegh Haghjoo(3), Elham Tabesh(2)
  • Review: Enhanced external counterpulsation and future directions: step beyond medical management for patients with angina and heart failure. [J Am Coll Cardiol. 2007]
  • Two-year clinical outcomes after enhanced external counterpulsation (EECP) therapy in patients with refractory angina pectoris and left ventricular dysfunction (report from The International EECP Patient Registry). [Am J Cardiol. 2006]
  • Review Enhanced external counterpulsation for ischemic heart disease: what's behind the curtain? [J Am Coll Cardiol. 2003]
  • One year follow-up of patients with refractory angina pectoris treated with enhanced external counterpulsation. [BMC Cardiovasc Disord. 2006]
  • Review: A new treatment modality in heart failure enhanced external counterpulsation (EECP). [Cardiol Rev. 2004]
  • Prospective Evaluation of EECP in Congestive Heart Failure: The PEECH Trial, Arthur M. Feldman, M.D., Ph.D., F.A.C.C.; C. Richard Conti, M.D., M.A.C.C., American College of Cardiology, 09/29/2006
  • Arora RR, Carlucci ML, Malone AM, et al. Acute and Chronic Hemodynamic Effects of Enhanced External Counterpulsation in Patients with Angina Pectoris. Journal of Investigative Medicine. 2001; 49(6):500-505.
  • Masuda D, Nohara R, Hirai T, et al. Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable Angina. European Heart Journal. 2001; 22:1451-1458
  • Werner D, Michelson G, Harazny J, et al. Changes in ocular blood flow velocities during external counterpulsation in healthy volunteers and patients with atherosclerosis. Graefe’s Archive for Clinical and Experimental Ophthalmology 2001; 239:599-602.
  • Barsness G, Feldman AM, Holmes DR, et al. The International EECP Patient Registry (IEPR): design, methods, baseline characteristics and acute results. Clinical Cardiology. 2001; 24:435-442
  • Michaels AD, Kennard, ED, Kelsey SF, et al. Does higher diastolic augmentation predict clinical benefit from enhanced external counterpulsation?: Data from the International EECP Patient Registry (IEPR). Clinical Cardiology. 2001; 24:453-458
  • Springer S, Fife A, Lawson W, et al. Psychosocial effects of enhanced external counterpulsation in the Angina patient: a second study. Psychosomatics. 2001; 42(2):124-132
  • Urano H, Ikeda H, Ueno T, et al. Enhanced external counterpulsation improves exercise tolerance, reduces exercise-induced myocardial ischemia and improves left ventricular diastolic filling in patients with Coronary Artery Disease. Journal of the American College of Cardiology. 2001; 37(1):93-99
  • Fujita M. Heparin and angiogenic therapy. Enhanced external counterpulsation for chronic myocardial ischemia. The Journal of Critical Illness. 2000; 15(11):629-636
  • Lawson WE, Hui JC, Lang G. Treatment benefit in the enhanced external counterpulsation consortium. Cardiology. 2000; 94:31-35
  • Taguchi I, Ogawa K, Oida A, et al. Comparison of hemodynamic effects of enhanced external counterpulsation and intra-aortic balloon pumping in patients with acute myocardial infarction. The American Journal of Cardiology. 2000; 86(11):1139-1141.
  • Lawson WE, Hui JC, Cohn PF. Long-term prognosis of patients with Angina treated with enhanced external counterpulsation: five-year follow-up study. Clinical Cardiology. 2000;23(4):254-258.
  • Huang W, Chen YC, Zheng ZS, et al. External counterpulsation increases capillary density during experimental myocardial infarction. Reprinted from the International Proceedings Division of the XXI Congress of the European Society of Cardiology. 1999;August 28-September 1 Barcelona (Spain).
  • Masuda D, Nohara R, Inada H, et al. Improvement of regional myocardial and coronary blood flow reserve in a patient treated with enhanced external counterpulsation - evaluation by Nitrogen-13 Ammonia PET -. Japanese Circulation Journal. 1999;63(5):407-411.
  • Werner D, Schneider M, Weise M, et al. Pneumatic external counterpulsation: A new noninvasive method to improve organ perfusion. The American Journal of Cardiology 1999;84:950-952.
  • Thadani U. Treatment of stable Angina. Current Opinion of Cardiology. 1999; 14(4):349-358.
  • Gloth S, Oken HA. Enhanced external counter pulsation: The Howard County experience in the first 18 patients. Maryland Medical Journal 1999; 48(4):155-156.
  • Caldwell CR, St. Pierre M, Talley JD. Enhanced External Counterpulsation. J Ark Med Soc. 1999; 96(2):54-56.
  • Arora RR, Chou TM, Jain D, et al. The Multicenter study of enhanced external counterpulsation (MUST-EECP): Effect of EECP on exercise-induced myocardial ischemia and Anginal episodes. The Journal of the American College of Cardiology 1999; 33(7):1833-1840.
  • Soran OZ, Crawford LE, Schneider VM, et al. Enhanced external counterpulsation in the management of patients with cardiovascular disease. Clinical Cardiology 1999; 22:173-178.
  • Cohn PF. Emerging treatments for refractory Angina. American College of Cardiology - Current Journal Review 1999; January/February:44-46.
  • Strobeck JE, Baklajian R, Hannon JC. The emerging role of enhanced external counterpulsation in cardiovascular disease management. The Journal of Cardiovascular Management 1998; September/October:23-29.
  • Froschermaier SE, Werner D, Leike S, et al. Enhanced external counterpulsation as anew treatment modality for patients with erectile dysfunction. Urologia Internationalis. 1998; 61:168-171.
  • Lawson W, Hui J, Guo T, et al. Prior revascularization increases the effectiveness of enhanced external counterpulsation. Clinical Cardiology 1998; 21:841-844.
  • Suresh K, Simandl S, Lawson WE. Maximizing the hemodynamic benefit of enhanced external counterpulsation. Clinical Cardiology 1998; 21:649-653.
  • Chou TM. Enhanced external counterpulsation. ACC Educational Highlights 1998; (Summer) 6-9.
  • Soroff HS, Hui JCK, Giron F. Historical review of the development of enhanced external counterpulsation technology and its physiologic rationale. Cardiovascular Reviews and Reports 1997; 18(11):34-40.
  • Strobeck JE, Baklajian R, Hannon JC. The emerging role of enhanced external counterpulsation in cardiovascular disease management. Cardiovascular Reviews and Reports 1997; 18(11):20-25.
  • Tartaglia J, Stenerson JF. Case studies: Enhanced external counterpulsation. Cardiovascular Reviews and Reports 1997; 18(11):26-33.
  • Fricchione GL, Hui JCK, Fife A, et al. Psychosocial aspects of enhanced external counterpulsation. Cardiovascular Reviews and Reports 1997; 18(10):37-41.
  • Lawson WE, Cohn PF, Hui JCK, et al. Enhanced external counterpulsation: U.S. clinical research. Cardiovascular Reviews and Reports 1997; 18(10):25-29.
  • Cohn PF, Lawson WE, Burger L, et al. Enhanced external counterpulsation: A new therapeutic option for patients who have failed coronary angioplasty and/or bypass surgery. Cardiovascular Reviews and Reports 1997; 18(5):10-17.
  • Lawson WE, Hui JCK, Oster ZH, et al. Enhanced external counterpulsation as an adjunct to revascularization in unstable Angina. Clinical Cardiology 1997; 20:178-180.
  • Lawson WE, Hui JCK, Zheng ZS, et al. Can angiographic findings predict which coronary patients will benefit from enhanced external counterpulsation? The American Journal of Cardiology 1996; 77:1107-1109.
  • Lawson WE, Hui JCK, Zheng ZS, et al. Improved exercise tolerance following enhanced external counterpulsation: Cardiac or peripheral effect. Cardiology 1996; 87:271-275.
  • Fricchione GL, Jaghab K, Lawson WE, et al. Psychosocial effects of enhanced external counterpulsation in the Angina patient. Psychosomatics 1995; 77:494-497.
  • Karim S, Sani A, Karom SK, et al. Enhanced external counterpulsation in the treatment and rehabilitation of coronary patients in Indonesia. Asian Cardiovascular & Thoracic Annals 1995; 3(1):26-28.
  • Lawson WE, Hui JCK, Zheng ZS, et al. Three-year sustained benefit from enhanced external counterpulsation in chronic Angina pectoris. The American Journal of Cardiology 1995; 75:840-841.
  • Cohn PF, Lawson WE. Role of enhanced external counterpulsation in Angina treatment. The Journal of Myocardial Ischemia 1994; 6(10):25-27.
  • Lawson WE, Hui JCK, Soroff HS, et al. Efficacy of enhanced external counterpulsation in the treatment of Angina pectoris. The American Journal of Cardiology 1992; 70:859-862.